What If I Miss A Dose
If you miss your dose of Dupixent, take the dose within 7 days of your missed dose. If you forget to take it within 7 days, skip that dose and wait until the next dose youre supposed to take.
To help make sure that you dont miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.
Eczema & Other Skin Conditions And Hair Loss
The health of your skin is linked to the health of your hair. Different skin conditions such as eczema and seborrheic dermatitis can impact your scalps health. Its not all that uncommon either up to 5% of the population suffers from scalp eczema.
While finding dandruff on your scalp doesnt mean youll start losing your hair, its still important to keep on top of your scalp and overall skin health. Youll want to know what to do if you discover a skin condition and how to approach hair retention or regrowth depending on the severity.
Response According To Blood Eosinophil Count And Feno Values At Baseline
To evaluate the clinical response according to the baseline blood eosinophil count, we compared patients with < 300 cells/L vs 300 cells/L . As shown in Table 3, ACT score , FEV1 and OCSs use were comparable in both groups after 12 months. Similarly, patients with a FeNO value < 25 ppb or 25 ppb showed no statistically significant differences at the end of the follow-up.
Table 3 Treatment Response According to Baseline Blood Eosinophil Count and FeNO
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Stopping Dupixent Cold Turkey
After six months on the medication, I decided to get off of it and go cold turkey. I wasnt using any medication and my skin was well.
In the summer of 2019, I was hospitalized due to staph infection and herpes simplex one virus. After a month of taking steroids in the hospital and many medications, my body was still really flared up. Once again my dermatologist fought for me to get back in Dupixent. Again, the insurance denied it and it took about two months to become approved.
The second time around on Dupixent, my skin cleared up again quickly. Within a few weeks starting I wasnt itchy at all and I was able to regain my sleep.
Does Dupixent Weaken The Immune System
Dupixent works by targeting a type of protein called an interleukin, that is involved in inflammation. Dupixent calms an overreactive immune system but it does not suppress the immune system. This leads to fewer and less severe symptoms of chronic inflammatory conditions, such as atopic dermatitis or asthma.
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Dupixent Cleared My Skin But Makes My Hair Fall Out
Is anybody who is on Dupixent experiencing hair loss?
My hair just started falling out in huge chunks since I started on this medicine, and it seems like other patients have been experiencing it.
Well that explains what is happening to me. Though my skin is taking forever to clear.
Yes. My daughter us experiencing significant hair loss. After only 2 doses. Help! Please!
How long have you been on it? I’ve only been on it for a month and have not noticed anything like that.
Been on it for only 4 weeks. About to take my 3rd dose.
Where is the hair loss from?
About a half inch behind my hairline, not an area that is characteristic of male pattern baldness. Plus, i’ve never had major hair loss like this before. It came on very suddenly.
On the other hand, right before I underwent Dupixent treatment, I was going through a very severe Topical Steroid Withdrawal that affected my entire body. My doctor said Teleogen Effluvium, or spontaneous hair thinning due to a stressful event, may be a possibility.
Remission Of Alopecia Universalis After 1 Year Of Treatment With Dupilumab In A Patient With Severe Atopic Dermatitis
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Is Dupixent Used To Treat Cancer Dyshidrotic Eczema Alopecia Or Psoriasis
But its possible that healthcare professionals may prescribe this drug off-label for other conditions.
If you have questions about Dupixents effectiveness for other conditions, talk with your doctor.
How Is Seborrheic Dermatitis Treated
To effectively treat the unpleasant symptoms of this skin condition, the condition itself has to be treated. Treating hair loss, hair thinning and flaking skin without treating the source of these symptoms can exacerbate this condition and make the symptoms worse.
There are a number of available treatment options to cure seborrheic dermatitis, including over-the-counter antifungal medications, natural treatment methods, and prescription medications.
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What Triggers A Seborrheic Dermatitis Flare
When seborrheic dermatitis flares up, it can cause increased redness, flaky rashes, and intense itchiness. Seborrheic dermatitis flare-ups can be rather hard to manage. These symptoms are uncomfortable and unpleasant for anyone experiencing them.
Flare-ups may be triggered by:
- Increased stress
- Harsh ingredients
How Long Does It Take For Eczema To Clear Up
The length of a flare-up will depend on what type of eczema you have, as well as the severity of the flare. With proper treatment, flare-ups may last one to three weeks, notes Harvard Health Publishing. Chronic eczema such as atopic dermatitis can go into remission with the help of a good preventative treatment plan.
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Does Scalp Eczema Cause Hair Loss
Eczema, the most common form of which is known as atopic dermatitis, causes a rash break out which leads to itchiness. Excessive scratching can lead to temporary hair loss caused by damaging your hair follicles.
Another kind of eczema, seborrheic dermatitis, creates flakey, greasy skin on your scalp often resulting in dandruff. Much like atopic dermatitis, temporary hair loss can occur through excessive scratching. However, one of the symptoms related to seborrheic dermatitis is the over secretion of sebum, which is an oil that your body produces that can then cause an overproduction of a natural yeast known as Malassezia. An excess of Malassezia on your skin can cause inflammation that is capable of preventing hair from growing nearby.
Dupixent And Other Medications
Below is a list of medications that can interact with Dupixent. This list does not contain all drugs that may interact with Dupixent.
Before taking Dupixent, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Its important not to get any live vaccines while taking Dupixent. For live vaccines, youre injected with a small amount of a virus so your body can learn to fight it. Dupixent may weaken your immune system, so a live vaccine could make you sick.
Before starting Dupixent, talk to your doctor or pharmacist about any vaccines you may need. You should get any live vaccines you need before you start taking Dupixent.
Live vaccines you should avoid when taking Dupixent include:
- measles, mumps, rubella
- prickling or tingling feeling like pins and needles in your arms or legs
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If Im Taking Dupixent For Asthma Do I Still Need To Use My Rescue Inhaler
Yes, you should still have a rescue inhaler even if youre treating your asthma with Dupixent. Dupixent is used to prevent asthma attacks from happening. However, if you have an asthma attack, you need a rescue inhaler to help open up your lungs quickly so you can breathe. Never use Dupixent to treat an asthma attack.
Talk with your doctor if while taking Dupixent your breathing worsens, your rescue inhaler isnt working, or you need to use your rescue inhaler more often than usual.
Financial And Insurance Assistance
If you need financial support to pay for Dupixent, or if you need help understanding your insurance coverage, help is available.
Sanofi and Regeneron Pharmaceuticals Inc., the manufacturer of Dupixent, offers a MyWay Copay Card Program. This may help lower the cost of your medication if you have insurance coverage for prescription drugs.
If you dont have insurance coverage for this drug, the Dupixent MyWay Patient Assistance Program may be able to help lower the cost of your treatment. For more information and to find out if youre eligible for support, call 844-DUPIXENT or visit the program website.
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Side Effects Requiring Immediate Medical Attention
Along with its needed effects, dupilumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dupilumab:
- Burning or dry eyes
- excessive tearing
- vision changes
Data Collection And Assessment
Demographic , asthma characteristics and comorbidities were collected at baseline. Number of exacerbations, pulmonary function tests, blood eosinophils count, fractional exhaled nitric oxide , Asthma Control Test score,12,13 and daily OCSs intake were assessed before starting the therapy with dupilumab and after 3, 6, and 12 months of treatment. Asthma exacerbations were defined as a disease worsening requiring 3 days of treatment with OCSs .14 One patient had 2 exacerbations treated with cycles of corticosteroids < 7 days from each other and were considered as the same exacerbation. Lung function tests were performed according to ERS/ATS guidelines.15
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How Long Do Dupixents Side Effects Last Are Any Long Term
Most mild side effects of Dupixent should get better on their own within a few days or a couple of weeks. But some may need treatment to help them clear up. If you have side effects that last longer than a couple of weeks despite treatment, talk with your doctor.
Some serious side effects of Dupixent, such as keratitis , may last a long time, even with treatment. Exactly how long side effects last will depend on how they respond to any treatments you may use for them.
If you have questions or concerns about how long Dupixents side effects may last, talk with your doctor.
Fda To Review Sanofi/regenerons Dupixent In Children With Uncontrolled Asthma
The US Food and Drug Administration will review Sanofi/Regenerons Dupixent as an add-on treatment for children aged six to 11 years with uncontrolled moderate-to-severe asthma.
Currently, Dupixent is approved as an add-on treatment for patients with uncontrolled moderate-to-severe asthma who are aged 12 years and older, and who have elevated eosinophils or oral corticosteroid dependent asthma.
Dupixent is a monoclonal antibody that inhibits interleukin-4 and interleukin-13 key drivers of the type 2 inflammation that plays a major role in asthma, as well as chronic rhinosinusitis with nasal polyposis , atopic dermatitis and eosinophilic esophagitis.
The supplemental biologics license application for Dupixent is supported by data that includes Phase III results evaluating Dupixent in addition to standard-of-care maintenance therapy in children with moderate-to-severe asthma with type 2 inflammation.
In the trial, Dupixent was able to significantly reduce severe asthma attacks and also rapidly improve lung function within two weeks in children aged six to 11 years.
The target action date for the FDAs decision on Dupixent in this indication is 21 October 2021.
Sanofi/Regeneron are also planning an EU regulatory submission for Dupixent in this patient population in Q1 20201.
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Disease & Conditions Interactions
Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions.
According to the FDA, diseases and medical conditions that are known to negatively interact with Dupixent include:
- Hypersensitivity reactions, such as hives and rash
- Certain eye problems, including conjunctivitis and keratitis
- Eosinophilic disorders eosinophils are a part of the immune system that responds to allergens by moving into the area and releasing toxins eosinophilic disorders occur when there are higher than normal levels of eosinophils throughout the body
- Acute asthma
- Atopic dermatitis along with asthma
- Parasitic infections
Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take Dupixent.
Tips For Traveling With Eczema
Editorial Team: Your personal Instagram has lots of travel photos. Any advice for planning a trip with eczema?Daisy: When I can, I always try to travel twice a year. I love traveling and it makes me so happy.
One of my favorite places to travel is to Cancun, Mexico. My skin seems to love the humidity and water from the sea. When traveling with eczema, I always take my necessary toiletries and more to avoid flare ups. I like to take my own hand soap because usually hotels have cheap soaps that arent good for our sensitive skin. I also always travel with my shampoo and conditioner for the same reason.
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Dupixent And Joint Pain
Dupixent may cause joint pain, according to the FDA.
Eczema Drug Dupilumab Spurs Hair Regrowth In Alopecia Totalis
In addition to effectively treating a resistant case of atopic dermatitis, the eczema drug dupilumab triggered hair growth in a young patient with longstanding alopecia totalis, investigators report.
The dual efficacy of the interleukin -4 receptor alpha antagonist, which was approved by the US Food and Drug Administration in March 2017 for the treatment of moderate to severe atopic dermatitis, may be explained by the immune characteristics shared by both conditions, Lauren R. Penzi, MD, from the Department of Dermatology, Massachusetts General Hospital, Boston, and colleagues write in a case report published online October 10 in JAMA Dermatology.
Atopic dermatitis is a TH2-mediated disease with elevated IL-4, IL-5, IL-13, and IL-31, and although the pathogenesis of alopecia totalis an advanced form of alopecia areata is not fully understood, recent studies point to a strong TH2 link as well, the authors write. Dupilumab improves eczema symptoms by blocking the signaling of IL-4 and IL-13 cytokines, which play a role in maintaining the immune response of TH2 cells.
The patient began weekly injections of dupilumab in 2017. After 6 weeks of treatment her eczema improved significantly and vellus hairs began growing on her scalp. “Nine months after beginning dupilumab treatment, the patient had grown pigmented, terminal hairs on approximately 60% of the scalp,” the authors write.
The authors and McMichael have disclosed no relevant financial relationships.
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