Assessing Systemic Pharmacodynamics Of Topical Finasteride
The first study on topical finasteride in humans was completed in 1997 by Mazarella et al.as a single-blind, placebo-controlled study, including 28 males and 24 females patients with AGA. Subjects were randomized to receive either 1.0 mL topical FNS 0.005% solution or placebo twice daily to the affected scalp for 16 months. Pharmacodynamic data revealed no significant change in plasma levels of total testosterone, free testosterone, and DHT between the groups. At sixth months, researchers observed a significant decrease in the rate of hair loss in the topical FNS compared to the placebo group. Patients opinion on the effectiveness of treatment was generally positive among the FNS group, with 73% of treated patients reporting high effectiveness, compared to 60% of placebo patients reporting no effect.
Does Finasteride Work Forever
Finasteride does not work forever, and if you stop taking finasteride, the natural balding process will resume. This means that you will lose any hair that has been regrown as a result of finasteride. The half-life of finasteride is 4-7 hours, which means that the dose drops by 50% within this time frame, after you have taken it. Because it is eliminated from the body at a rapid rate, it is important to continue to take finasteride. A continuous dosing regimen allows a sufficient amount of finasteride to be sustained in your body in order for it to work. Once you stop taking it, testosterone will convert to DHT, which will begin to shrink the hair follicles again.
Interactions With Other Medications
An interaction is when a substances changes the way a drug is intended to work. It can be harmful or prevent the drug from working at all. To help prevent interactions, it is best to speak with your doctor prior to taking any medications, vitamins or herbs.
To find out how finasteride oral tablet might interact with something you are currently taking, tal to your doctor of pharmacist.
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Finasteride Results Months 7
âMonths 7-12 are the time period where you retained hairs and new growth are really coming together.
During this time your full Finasteride hair potential is becoming realized. Most men should expect much of the full results to be in after consistent treatment for 12 months.
Experiment with new styles that fit your new âdo, and expect comments and compliments from friends and family as changes should be pretty obvious at this time.
Studies Of Finasteride For Receding Hairlines
Although there are numerous studies on finasteride as a treatment for hair loss, only a few look at its effects on hair loss around the hairline.
For example, a 1999 study published in the Journal of the American Academy of Dermatology, which assessed hair growth by counting mens hair in the frontal scalp, found that daily use of finasteride caused a significant increase in hair count over the course of one year.
As well as increasing hair count around the hairline, finasteride also produced an improvement in the appearance of the mens hair in a photographic assessment.
In short, based on the findings of this study, finasteride appears to produce a real improvement in hair growth around the hairline.
Other research shows that finasteride reduces hair loss in other areas of the scalp commonly affected by male pattern baldness.
For example, research also shows that finasteride reduces hair loss near the vertex scalp, or crown.
In a separate study, also published in the Journal of the American Academy of Dermatology, a team of researchers analyzed the effects of finasteride on men with male pattern baldness over the course of two one-year trials.
The researchers found that finasteride produced a clinically significant increase in hair count by measuring hair growth at the vertex scalp.
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See Finasteride Before And After Pictures
Are you thinking about taking finasteride to battle your hair loss? You probably have many questions, including what sort of results you might expect. Along with plenty of before and after pictures, weve included all the information you need to decide if finasteride might be right for you and how to get finasteride online.
What To Expect When Using Finasteride
The typical user should not expect dramatic regrowth from finasteride and certainly not overnight. Because hair growth is subject to the lengthy hair growth cycle, you can expect to see little in the way of results for the first three months. After the three-month mark, you can expect the first signs of regrowth which will become more pronounced at six months. You get your final results with finasteride at around the 12-month mark, after which you are unlikely to grow further hair.
One thing to look out for if taking finasteride for the first time is the appearance of side effects, which will be covered in more detail shortly.
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Topical Finasteride Vs Placebo
In 1997, the first clinical trial on topical finasteride as a treatment for male pattern baldness, which lasted for 16 months, was completed. In this study, a 0.005% finasteride solution applied twice a day was found to decrease the rate of hair loss compared to placebo with just six months of application.
How Well Does Propecia Work
Last Updated on August 25, 2020 by Hold the Hairline Team
Does Propecia work? The answer is yes. If youre looking to halt your hair loss, this is one of the proven heavy hitters of hair loss prevention. Propecia is verified as a potent DHT-inhibitor, eliminating hair loss from the source of the problem. Estimations put the number of Americans at over one million with prescriptions for Propecia to counter their hair loss condition.
Before we get started, please keep in mind this is not medical advice, all decisions before taking a medication such as Propecia should be discussed with your doctor first.
Mens Rogaine an Alternative or Supplement to Propecia
Many people have had a great deal of success combining this drug with minoxidil and ketoconazole. Propecia works at the root of the problem, significantly decreasing DHT levels. Minoxidil stimulates new hair follicles growth via a topical application on the scalp. Ketoconazole cleanses the scalp, nuking any scalp DHT that wasnt first destroyed internally by Propecia.
These three treatments, when used together, are very effective at preventing further hair loss. Furthermore, it is even possible to regrow previously lost hair with Propecia.
In this informational page, we link to some of the most popular clinical studies done on Propecia hair loss treatment. We then discuss reasons people may take or not take the drug, our take on its validity as a hair loss solution, and the steps you need to take if you want to get it.
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How Propecia Was Developed
Sometimes during clinical trials in humans, drug companies discover side effects that are actually a bit helpful for unrelated ailments. Perhaps the most famous example is sildenafil citrate, better known as Viagra a medication developed by Pfizer to treat high blood pressure and angina .
During clinical trials, researchers found the sildenafil citrate wasnt doing much to help peoples blood pressure, but men were experiencing well, a different, unexpected side effect. Of course, this led to the repurposing and redevelopment of said drug.
Like Viagra and a few other medications, finasteride isnt used for its original intended purpose. Merck developed a medication called Proscar to treat enlarged prostate glands. As with Viagra, participants in the clinical trials reported a fortunate side effect. This time, it was additional hair growth.
Because the drug was already approved for a different purpose, Merck decided to repurpose it and create the first hair loss medication in a pill form.
After additional clinical trials to determine dosage in 1997, the FDA approved a 1mg dose to treat male pattern baldness, and Propecia was born. Propecia became the first drug of its kind to treat androgenic alopecia and remains extraordinarily popular today.
Hair Loss Treatments At Keeps
Keeps is more restrictive with its products usage than other hair treatment companies are. The companys two treatment options are only recommended for use by men, and customers must get a prescription before purchasing finasteride. Moreover, there is no money-back guarantee. However, the price is also on the lower side, making Keeps an excellent choice for male consumers who are looking for treatment for their hair loss at an affordable price.
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The Best Finasteride Dose For Hair Loss
The prescribed Propecia dosage of 1mg finasteride every day undoubtedly works for hair loss.
Increasing this dose is not likely to have an appreciable effect on hair. But nor is it likely to increase the risk of side effects either.
Similarly, evidence suggests that decreasing the dose even to as low as 0.2mg per day wont be any less effective for hair loss. But it probably wont reduce the incidence of side effects either. You could even get away with taking Propecia every other day possibly even every four days. As shown, this is not likely to have a significant effect on DHT levels.
But the approved dose for hair loss Propecia has been trialled and tested extensively.
In theory, lower doses would be just as effective. But a lower dose does not necessarily reduce the chance of side effects.
Krox20 Protein Scf Gene
Researchers from University of Texas Southwestern Medical Center in Dallas have identified a protein called KROX20, which switches on cells in the skin and tells them to become hair. Furthermore, these hair precursor cells then go on to produce a protein called stem cell factor , which plays a critical role in hair pigmentation.
When the SCF gene was deleted in the hair precursor cells in mice, they grew gray hair that turned white with age. Moreover, when the KROX20-producing cells were removed, the hair ceased growing, and the mice became bald.
With this knowledge, we hope in the future to create a topical compound or to safely deliver the necessary gene to hair follicles to correct these cosmetic problems, said Dr. Lu Le, associate professor of dermatology at UT Southwestern.
Future work by the team will focus on finding out whether KROX20 and the SCF gene stop functioning properly and lead to male pattern baldness.
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Tinkering With The Standard Dosage
There is no benefit to taking more than 1mg daily for your hair loss. There is zero chance you will see better results, and will only be more likely to experience unpleasant side effects. You will understand why this is so as you read through this article.
The aim of this discussion is to see if it is possible to take a dosage that is lower than 1mg daily.
A lower dosage might interest balding men for many reasons:
Keeps Reputation And Customer Service
Keeps has an A+ rating from the Better Business Bureau, and customer ratings average about 3.5 out of 5 stars. On Trustpilot, there are only two reviews, which give Keeps 2.9 out of 5 stars.
Most negative reviews are about people being charged after they tried to cancel, or having other difficulties with canceling. Once a prescription is processed for a billing cycle, it cant be returned or canceled. Keeps responded thoroughly to both negative and positive reviews.
Other reviews state that Keeps has prompt customer service. Reviews of the products themselves are generally positive across sites.
The Keeps website provides options to text, call, chat with, or email their customer service team.
The side effects of each medication are different.
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Is Finasteride More Effective Than Other Treatments
When it comes to tackling hair loss and male pattern baldness, Finasteride is one of the most effective treatments available on the market .
There are other hair loss treatments out there, such as Regaine Extra Strength Solution which contains the active ingredient Minoxidil. Regaine comes as either a lotion or foam and is an effective option for treating hair loss, so it depends on what form you would like your treatment to take oral or topical. Regaine is available over the counter.
Another alternative hair loss treatment is Avodart, which comes in capsules and contains the active ingredient dutasteride. Avodart works in a similar way to Finasteride and is another effective treatment that has positive user reviews. Avodart is prescription-only.
Hair growth tablets, supplements, and vitamins are available from online stores and high-street shops, but these cannot be proven to be effective and in some cases, are not safe to use.
Of course, there are other non-medicinal options for treating hair loss such as hair transplants . Alternative remedies such as homoeopathy and acupuncture are sometimes used, but there is little evidence to suggest that these work.
If you are looking for a safe and effective hair loss treatment, then it is best to stick to prescription medication such as Finasteride.
If in doubt, you can speak to your doctor or a medical professional to see what they advise.
Getting The Most From Your Treatment
- Each time you collect a new supply of tablets from your pharmacy, make sure they look to be the same as you have had before. This is because there is a high-dose brand of finasteride tablet available for the treatment of a different condition. If you are unsure that you have the correct tablets, ask your pharmacist to check for you.
- Your hair growth may start to improve within a few months, although it can take up to a year or so for you to notice the full benefit. You will need to continue treatment to maintain this effect, as the balding process returns when you stop.
- Finasteride may cause harm to an unborn baby. Because of this, women who are pregnant should not handle the tablets. Also, very small amounts of finasteride will be in your semen while you are taking this medicine. If you need further advice about this, speak with your pharmacist or doctor.
- If you are having an operation or any medical treatment, tell the person carrying out the treatment that you are taking finasteride. This is because finasteride can interfere with a blood test used to detect prostate cancer, so you must tell your doctor about taking finasteride if you need this test.
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