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What Is Aga Hair Loss

Aga Treatment At Azabu Skin Clinic

My TOP 3 Prescription FREE Topical Solutions for Hair Loss Beginners! AGA, MPHL

Treatment 1


ãPRP Treatmentã

PRP is a regenerative treatment which promotes hair regeneration. By using the patient’s own growth factors , repair and regeneration of cells is made possible, safer, and more effective.The first procedure for this treatment is collecting the patient’s blood.After which, the blood is placed in a state-of-the-art centrifuge machine so the platelets that contain the high concentration of growth factors can be extracted. These platelets – called the PRP, is then injected to the patient’s scalp.

ãRisk / Side Effectsã

Because the extracted PRP comes from the patient’s own blood, there is almost no negative side-effect. There is very minimal chance of allergic reactions and infection can occur only if the treated area is unclean. The results of this treatment varies per individual.PRICEï¼1timeãï¿¥95,000ï½ï¿¥160,000

Follea Lifestyle Wig: Hello A Very Wiggy Week

This past week has been a busy busy wig week. Last Sunday I went to Milano Wigs in Los Angeles to buy the WiGrip. The WiGrip is this handy dandy little strap that ties around your head like a comfy headband and keeps a wig in place without the need for clips or a comb. Amen! I kid you not, this little invention is amazing. Ive seen several other similar grips online, they all look the same and probably function exactly the same as well.

Whilst at Milano Wigs I was taken in by the massive amount of wig supply they had there, a showroom filled with a ton of wigs that you can just try on by yourself. At first I felt awkward, out of place and a bit timid, but pretty soon I was flinging those bad girls on my head left and right. I think the plastic wig head fumes got to me and I ended up purchasing 2 wigs, that quite frankly are likely not going to see a lot of wear time. The wigs are quality wigs, dont get me wrong, but the color isnt exactly right for me and they dont look as good on me as my Freeda Wig , or my new Follea Wig but more on that later.

Amino Acids And Proteins

Protein malnutrition, such as in kwashiorkor and marasmus, can result in hair changes that include hair thinning and hair loss .

One study examined the role of L-lysine, an essential amino acid that may play a role in iron and zinc uptake. Addition of L-lysine to iron supplementation resulted in a significant increase in mean serum ferritin concentration in some women with chronic TE who failed to respond to iron supplementation alone . Although interesting, there is limited data available, and the role of L-lysine should be investigated further.

In terms of other amino acids and proteins, no clear conclusions may be drawn about the role of supplementation in hair loss. While trials of amino acid and protein supplements have been published, they are formulated with a variety of nutrients, and therefore it is unclear what role, if any, is played by amino acid and protein supplementation in the absence of known deficiency.

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How Can Chronic Te Be Distinguished From Aga

How often chronic TE is associated with AGA is difficult to say, but given the high frequency of AGA among Caucasians, it must be a common observation.

Clinically, when AGA is obvious there would be no difficulty to recognize it. Modest cases are more troublesome, but trichoscopy is of a major help. The ratio between the hair density at the vertex and that at the occiput should be less than 1.49 MWT is a simpler and invaluable diagnostic tool providing a measure of the respective severities. The prevalence of vellus hairs that exceeds 10% indicates AGA that deserves treatment. Instead, a 10% vellus prevalence is tolerable.

What Happens To Hair Follicles

What is AGA Hair Loss? Androgenetic Alopecia

Hair growth happens in different cycles or stages. With AGA, the active stage of the hair growth cycle gets cut off prematurely. Normally, the anagen phase lasts anywhere from two to six years, but androgenetic alopecia causes the cycle to become shorter and shorter from cycle to cycle. Not only that, but it also takes longer for new hair to start growing back after it is shed. This is because the hair follicles are undergoing a physical change called miniaturization, in which the hair follicles shrink in size and reduce the thickness of hairs along with them.

Miniaturization happens because, for those with AGA, some hair follicles seem to be genetically oversensitive to dihydrotestosterone , which is a hormone that is converted from testosterone with the help of an enzyme in the follicles oil glands. DHT binds to the oversensitive receptors in the hair follicle and shrinks it over time.

In androgenetic alopecia, dihydrotestosterone also causes a decrease in the growth phase of the hair, making each hair progressively thinner with each hair cycle,” Dr. Ranglani said. “Ultimately, what results is thin, fine, ‘vellus’ hair.

And eventually, the follicle might stop producing hair altogether.

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Isolation And Culture Of Hdpcs

DPCs were isolated from the isolated hair follicle bulb and transferred to a polystyrene Petri dish coated with bovine typeI collagen. The characteristics of the DPCs were assessed as shown in Supplementary Figure 1. Penicillin , streptomycin , and 20% heat-inactivated fetal bovine serum were added at 37°C and in a 5% CO2 humidified atmosphere and cultured in Dulbecco’s modified Eagle’s medium. The culture medium was changed every 3 days. The explants were maintained for several days, and when cell growth reached the subfusion state, the cells were harvested in Hank’s equilibrium salt solution with 0.25% trypsin/10 mM EDTA and passaged at a ratio of 1:3. Then, the DP cells were cultured in DMEM containing 10% fetal bovine serum, and the third-generation cells were used in the experiment .

Clinical Features Of Aga In Women

Androgenetic Alopecia also known as female pattern hair loss in women is a genetic condition and is caused by androgens in both men and women. The incidence of this condition is the same for men as it is for women. It beings between the ages of 12 and 40 years and is inherited in a polygenic manner. The hair follicles that are susceptible to this condition, the dihydrotestosterone will bind itself to the androgen receptor and then the hormone-receptor complex leads to activating the genes that are ultimately responsible for a gradual change to miniaturized follicles from large terminal follicles.

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How Is Androgenetic Alopecia Diagnosed

If you think youre experiencing androgenetic alopecia, its important to see your doctor since hair loss can be the symptom of a more severe illness or condition. Your doctor will talk to you about your general health and ask about other symptoms you might be experiencing. Your clinician might also want to do a blood test to check your levels of thyroid hormone, androgens, iron or other substances that can affect hair growth.

Sometimes, we may use a specialized instrument called a trichoscope to evaluate the extent of hair follicle thinning and to decide the best course of treatment,” said Dr. Ranglani.

Genetics & Autoimmune Disorders

4 Primary Ways of Treating Hair Loss – Male Pattern Baldness

Although there are genetic and as well as many hormonal causes for female hair loss, the most common cause of hair loss in women is due to androgenic alopecia or AGA.

Androgenic Alopecia

AGA is a genetic cause of hair loss which is autosomal dominant with complete penetrance- meaning that some degree of hair loss will occur in all people carrying the gene for AGA.

AGA occurs due to androgens and their effect on hair follicles sensitive to these male hormones. Androgens are present in both men and women but are only present in small amounts in women. Despite the small number of androgens in women, hair follicles in women with AGA are sensitive to these males hormones- causing hair loss. AGA is more common in Caucasians.

Androgen levels in AGA can cause :

  • A shorter cycle of hair growth leading to hair loss
  • Growth of shorter, thinner hair strands causing hair to look thinner
  • Delays in new hair growth decreasing the replacement of lost hair with new hair.

Alopecia Areata

Alopecia areata is an autoimmune disease, which occurs when the bodys own immune system mistakenly attacks healthy hair follicles and destroys them. In most cases, the damage is not permanent.

However, the hair loss may be extensive if the onset is before puberty. When alopecia areata occurs, the missing patches usually grow back in 6 months to a year.

In rare cases, people may lose all of the hair on their scalp and body, a condition called alopecia universalis.

Scarring Alopecia

Congenital Hypotrichosis

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Male Pattern Hair Loss

As mentioned above, AGA in men can begin as early as the teens. Usually, when AGA starts in these younger years, the extent of the hair loss will most likely be considerable by the time the person has reached their mid 30s. The most common progression and patterns are represented by the Norwood Scale of Male Androgenetic Alopecia.

Patterns of AGA in men can and do differ from this scale, and not everyone will progress through the entire scale. Many men will lose a bit of hair in the temples and never any more than that.

The progress of hair loss in AGA is one of thinning, rather than loss. As hair begins to be affected by DHT, the hair follicles are reduced in size, and therefore produce smaller and finer hairs. These hairs become finer as they fall out and replace themselves. This is known as miniaturization. Another symptom of AGA is the shortening of the hair growth cycle. As hair loss progresses, the finer hairs will have a shorter time period from when they start growing and when they fall out. Finally, the length of the resting stage can also be increased, leading to areas where hair is not growing. It is important to note that hair follicles in the kenogen stage are not necessarily dead, and the goal of many hair loss treatments is to return these follicles to the anagen stage, and reduce the length of the telogen and kenogen stages.

Complementary And Alternative Medicine

Complementary medicine refers to practices used concomitantly with conventional therapies, while alternative medicine is used in place of these therapies. The NCCIH divides CAM approaches into three main categories: natural products mind and body practices and other . CAM provides the option to choose promising, low-risk, adjuvant and alternative therapies. Herein, we provide a comprehensive review of CAM treatment options for alopecia, with most evidence in androgenetic alopecia and alopecia areata . Table 1 provides an in-depth summary of these investigations.

Table 1.

Summary of clinical investigations on complementary and alternative treatments for alopecia

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Effectiveness And Safety Of Botulinum Toxin Type A In The Treatment Of Androgenetic Alopecia

Zigang Zhao

1Department of Dermatology, Hainan Hospital of PLA General Hospital, Sanya, Hainan Province, China


1. Introduction

Hair loss represents the most frequent and distressing clinical complaint encountered by dermatologists in clinical practice. Androgenetic alopecia , telogen effluvium, and alopecia areata are the three most common types of hair loss, with AGA being the most prevalent type in dermatology practice. AGA or pattern baldness, characterized by a progressive miniaturization of the hair follicle, is a nonscarring hair loss disorder that predominantly affects up to 80% of men and 50% of women during adolescence and postadolescence . The prevalence varies across ethnic groups, with higher prevalence rates reported in Caucasian men and women than in Asian and black men. The pathogenesis of AGA is highly variable and remains elusive however, the presence of dihydrotestosterone and degree of genetic predisposition plays a causative role in its development . There are several traditional treatment options available for the treatment of AGA however, their effectiveness remains limited. Therefore, a safe and effective treatment modality with fewer side effects that can significantly benefit patients with AGA in a dermatology practice setting is highly desirable.

The present study is aimed at evaluating the safety and effectiveness of BTA on the treatment of AGA.

2. Methods

2.1. Participants
2.2. Study Design
2.3. Botulinum Toxin Injection

How Do I Tell If My Hair Loss Is Aga Te Or Related To Other Factors 9photo

How to Deal with Androgenic Alopecia (AGA)

Hi, i am a 21 year old female who started experiencing hair loss nearly a year ago after stopping Diane 35 which i took for irregular periods.I did notice my mid part was widening and it is important to note that mom has suffered from hair loss. In March 2017 i started LoLo 10mcg/1mg and noticed my hair thinning and shedding which made me stop the ocp and i still lose 75 strands in the shower.I have excess facial and body hair along with being overweight while suffering with anxiety. please help

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Point : If You Want To Assess The Degree To Which Aga And Te Are Present You Could Have A Biopsy Or 5 Day Modified Hair Wash Test I Dont Think These Are Really Needed

For your physicians/specialists who think that AGA is not a diagnosis here for you, a biopsy or 5 day modified hair wash test could help prove them wrong . This is a wonderful test but adds to the stress of collecting hairs so Im not always in favour of it. Biopsies leave scars but if interpretted by a knowledgable dermatapathologist, they can be very helpful.

But, lets be clear. A biopsy showing a terminal to vellus hair ratio of less than 4:1 taken from your mid scalp area puts to rest any argument about whether AGA its present of not. End of discussion. A 5 day modified hair wash test showing less than 100 hairs and more than 10% hairs being tiny 3 cm hairs also points to an underlying AGA.

Of course, simply examining the scalp with trichoscopy can also confirm this diagnosis but not all specialists are skilled with trichoscopy. If a specialist knows how to use a handheld dermatoscope, we dont even need biopsies or hair collections to diagnose AGA. If they dont then yes, we need to go to the extra effort to prove it.

Studies With Positive Results

A recent pilot study by Anitua et al. evaluated the use of plasma rich in growth factors in 19 subjects with AGA. Subjects were given 5 injections of PRP enhanced with platelet-rich growth factor activator to provoke release of growth factors and morphogens from the specimen . Compared to baseline, all outcome measures showed positive results after 1 year of follow-up. Mean hair density, hair diameter, and terminal/vellus hair ratio were among the measures showing statistically significant improvement . Histomorphometric evaluation also favored the use of PRP, showing improvement in epidermal thickness, perifollicular neoangiogenesis, and terminal/miniaturized hair ratio , as well as decreased perivascular inflammatory infiltrates. Overall, patients were satisfied with their clinical improvement.

Alves and Grimalt led a 25-subject randomized, blinded, half-head investigation, among which 22 completed the trial. The subjects were divided into 2 groups: group A, which received 3 mL of PRP on the right half of the head and 3 mL of saline placebo on the left, and group B, which received the same 2 solutions on opposite sides of the head. After 3 and 6 months, statistically significant improvements were detected in mean anagen hairs, mean telogen hairs, hair density, and terminal hair density in PRP-treated areas when compared with baseline . Mean total hair density was the only measure found to be significantly increased in PRP versus placebo-treated areas .

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