Alternative Treatments For Fphl
Low-level laser light therapy
Red or near-infrared laser light has been reported to promote tissue repair and regeneration and, more recently, low-intensity light laser therapy has been demonstrated to stimulate hair growth, probably by increasing the mitotic rate of the hair follicle stem cells or follicular keratinocytes . Additionally, LLL may modulate inflammation by increasing TGF-1 and IL-10 while reducing proinflammatory cytokines and prostaglandin E2 . Usually wavelengths between 600 and 1550 nm , emitted by helium-neon and fractional erbium glass lasers, are used. Several studies have shown that LLL may improve FPHL but the effect is generally modest and, in a male study, although hair count increased, no differences with global photographs were observed . Adverse effects are few but may include headache, erythema, pruritus, burning, pain, and mild paresthesia .
Platelet-rich plasma is produced by centrifuging a patients own blood, concentrating the platelets, and injecting the concentrate into the patients scalp in affected areas. In addition to platelets, PRP contains numerous growth factors, chemokines, and cytokines . Results are promising however, evidence is very limited and studies that have been performed have used different protocols without sufficient follow-up .
Does Exercise Reduce Dht
Slow and steady exercises like yoga or jogging will contribute to balancing the DHT levels in your body. On the other hand, studies claim that extreme exercises like bodybuilding will boost the production of DHT as the overdoing of workouts aggravate Pitta dosha in your body.
Hence, to reduce the excess production of DHT, you should have a moderate and regular exercise plan for 3 5 days a week.
The Last Word
While you strive to combat your DHT hair loss, drugs that modulate your hormones may also have unwanted side effects. Whereas, Ayurveda, with its natural and medicinal herbs, help you keep the DHT levels in control without adverse effects.
At Vedix, we understand your underlying hair loss factors by analyzing your current dosha levels and craft a customized hair care regimen based on your hair needs.
Hair Cycle Of Growth And Rest
Like your skin and nails, your hair goes through a finely tuned cycle of growth and rest. Hair loss can occur at any time in the cycle. There are 3 phases in a hair cycle:
- In the first stage, your scalp hair is continually growing. This is called the anagen phase. In this phase, your hair grows about 12cm per month. About 90% of your hair is in this stage at any one time. It lasts between 25 years.
- The second stage is call the catagen phase, which is when growth stops. About 13% of your scalp hair is in this phase at any one time. It lasts for 23 weeks.
- The third stage is called the telogen phase. This is a resting phase and it lasts between 14 months. About 10% of your scalp hair is in this phase at any one time.
At the end of its resting stage, a hair goes through a shedding phase, which normally results in the growth of a new hair. When a hair is shed, it’s replaced by a new hair from the same hair follicle, located just beneath your skin surface.
Male or female hereditary hair loss is caused by genetic or hormonal influences. It is also called androgenic alopecia because it is affected by the hormones called androgens. These are present in both men and women, but in different quantities.
Your risk of hereditary hair loss increases if you have relatives who have experienced hair loss. Your genetic blueprint for hair loss will affect things like:
- how old you are when hair loss begins
- how fast you lose hair
- the pattern and extent of your hair loss/ baldness.
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Treatment For Dht Hair Loss In Womenby Dr Raymond Konior On July 18 2019
Dihydrotestosterone is a hormone that causes hair loss in both men and women. In fact, hormones are the primary cause of hair loss in both sexes. Yet DHT and the nature of male and female hair loss are poorly understood by the public at large. Thats why Chicago, IL hair restoration specialists Dr. Raymond J. Konior and Dr. Sahar Nadimi take time to discuss the nature and causes of hair loss with their patients.
Right now, our team would like to go over hair loss treatment for women whove experienced thinning hair as a result of DHT. Lets go over the basics of DHT first and then cover some ideal options for female hair loss treatment.
Clinical Study I: Low
General characteristics of the subjects
A total of 48 male and female subjects diagnosed with moderate androgenetic alopecia were recruited and randomly assigned to an AR68 low-dose treatment group or placebo group . In the AR68 low-dose treatment group, 2 of 24 subjects dropped out thus, 22 subjects completed the study. The mean age was 42.4±8.10 years, and the male to female ratio was 8:14. In the placebo group, one of 24 subjects dropped out , with 23 completing the study. The mean age of the placebo group was 42.4±6.69 years, and the male to female ratio was 6:17. There was no statistically significant difference between the two groups based on group homogeneity analysis performed to confirm the validity of randomization .
Table 1 Demographic characteristics of the subjects in clinical study I.
Analysis of hair density and total hair counts
Images of the change in hair loss following 24 consecutive weeks of application of SAMiRNA-AR68 at 0.5 mg/ml and placebo products. Representative photographs of the forehead hairline and vertex of the two groups at baseline and 8, 16 and 24 weeks after 0.5 mg/ml AR68 and placebo treatment three times per week. The phototrichogram analysis was performed at baseline and at 16 and 24 weeks. Representative graph of the percentage of total hair count increments at 16 and 24 weeks compared to baseline.
There was no significant difference between the AR68 0.5 mg/ml treatment group and the placebo group.
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Having Too Little Dht
High levels of DHT can increase your risk for certain conditions, but having too little DHT can also cause problems in your sexual development as you go through puberty.
Low DHT may cause delays in the onset of puberty for all sexes. Otherwise, low DHT doesnt appear to have much effect on women, but in men, low DHT may cause:
- late or incomplete development of sex organs, such as the penis or testes
- changes in body fat distribution, causing conditions such as gynecomastia
- increase in risk of developing aggressive prostate tumors
Isn’t Hair Loss Just A Cosmetic Issue
Male pattern hair loss can have a negative psychological impact. Studies have shown that hair loss can be associated with low self-esteem, depression, introversion, and feelings of unattractiveness. This is reinforced by attitudes in Western society, which place great value on youthful appearance and attractiveness. Some studies have shown that based on appearance alone, men with hair loss are seen as less attractive, less assertive, less likeable, and less successful than men without hair loss.
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The Safety Of Samirna
One of the limitations in developing RNAi therapeutics for clinical applications is cytotoxicity and systemic toxicity, including innate immune stimulation. To evaluate the cytotoxicity of AR68, we performed a cell viability assay in HFDP and keratinocyte HaCaT cells at effective concentrations . Neither HFDP nor HaCaT cells showed cytotoxicity up to 20 M AR68 . We also evaluated whether AR68 induces nonspecific innate immune stimulation in human PBMCs. AR68 was treated at concentrations up to 10 M, and proinflammatory cytokines related to TLR3 signaling were analyzed after 6 h. AR68 did not induce proinflammatory cytokines, including interleukin -1, IL-6, interferon-gamma , and tumor necrosis factor-alpha , in PBMCs compared to nonstimulated negative controls as a positive control, concanavalin A significantly induced proinflammatory cytokines . Taken together, these results demonstrate that AR68 does not induce cytotoxicity or innate immune stimulation at 10 µM, and these results guided determination of the effective dose of AR68 to be used in clinical applications.
What Treatments Are Available For Male Pattern Hair Loss
Current treatment options include:
- Finasteride tablets
There is some evidence that ketoconazole shampoo may also be of benefit, perhaps because it is effective in seborrhoeicdermatitis and dandruff. Low-dose oral minoxidil can increase hair growth on the scalp, but may also result in generalisedhypertrichosis and other adverse effects .
Low-level laser therapy is of unproven benefit in pattern balding one device has been approved by the FDA for marketing. Platelet-rich plasma injections are also under investigation. Further studies are required to determine the magnitude of the benefit if any.
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How Can You Stop Your Hair Loss
A quick web search provides a long list of products and treatments that claim to slow or reverse balding. It can be overwhelming to know where to start, so heres an overview of some of the most popular treatments to get you started:
- DHT blockers and inhibitors Can have an excellent success rate. Inhibitors lower DHT production, while blockers prevent DHT from binding to your hair follicles.
- Finasteride is an oral prescription DHT blocker
- Dutasteride inhibits DHT production.
Inflammation Causes Perifollicular Fibrosis
Inflammation and immune response alone is enough to cause some types of hair loss , but I suspect most of the irreversible MPB is caused by perifollicular fibrosis.
Chronic inflammation of the hair bulge gradually leads to irreversible scarring of the follicle, which we call perifollicular fibrosis. Its pretty clear why this causes hair follicle miniaturization, a receding hairline, a bald spot and eventually total loss of hair on the top of the head. It makes sense that the follicles morphing from healthy to irreversibly damaged would result in the slick, shiny, tight scalp appearance of bald men.
But its all very well saying DHT causes inflammation, which may lead to extensive perifollicular fibrosis, causing irreversible damage to the hair follicles but it still doesnt answer the original question: Why does DHT set this destructive process in motion in some people and not others?
Fibrosis typically results from chronic inflammation defined as an immune response that persists for several months and in which inflammation, tissue remodelling and repair processes occur simultaneously
Its the prolonged immune response that were really interested in here.
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What Is A Dht Blocker And How Does It Work
Hormones are regularly in flux. DHT blockers target the receptors responsible for generating imbalanced amounts of testosterone and slow them down so you can enjoy a richer head of hair.
These synthetic hormones are powerful and effective when taken as prescribed, able to encourage steady hair growth and fill out hairlines. Blockers keep DHT from forming at all, while inhibitors slow down the production rate. It may sound like a negligible detail, but this minor difference is key in knowing which solution will work best for you. Testosterone supplements are usually taken daily, sometimes twice a day, to effectively change your bodyâs natural functions.
DHT blockers can be prescribed in pill form or in specialized shampoos provided by your doctor. You may be advised to bolster your diet, as well, since there is evidence of vitamin B12 deficiencies contributing to the onset of hair loss.
What Is Dht What Does It Do To Your Hair
Dihydrotestosterone is a derivative of the testosterone hormone . An enzyme called 5-reductase is responsible for the conversion of testosterone to DHT molecules in various tissues like prostate gland, liver, brain, skin along with hair follicles.
DHT is crucial for the development of male biological characteristics like facial hair, muscles, deep voice, etc. in an adult male. At normal rate, about 10 % of Testosterone produced in men is converted to Dihydrotestosterone by 5-reductase enzymes.
But, when produced in excessive levels, DHT molecules bind to your hair follicle receptors, blocking the blood supply to your follicle cells. This prevents the dermal papilla from receiving essential nutrients for hair growth, resulting in the miniaturization of your hair follicles.
While it is a very common hair loss factor in men, termed as Androgenic alopecia , women too experience hair loss due to DHT imbalance .
As per the study conducted by medicine and dermatology departments of University of Florida and University of California, hair follicles in female frontal scalp line contain 40% lower androgen receptor content than in the front line follicles in males
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How Is Dht Generated
DHT is produced as a byproduct of testosterone. It is estimated that around 10% of the testosterone the body produces is converted by the 5-Reductase enzyme in tissues such as the skin, liver, prostate, and hair follicles. It is then released in the bloodstream from where it travels to androgen receptors on various tissues to produce predetermined changes.
Can You Tell Me More About Dht Blockers
We can! While you can go down an internet rabbit hole and read about all kinds of DHT blockers, theres only one thats proven to work. And that one is finasteride. Finasteride is a prescription tablet that effectively blocks DHT and stops further hair loss, including receding hairlines. It works by binding to the 5-Reductase enzyme, effectively inhibiting your body from producing DHT in the first place.
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Female Pattern Hair Loss
Women with hereditary baldness rarely develop bald patches. Instead, you experience a general thinning of their hair, especially over the top of your head or crown, while maintaining a frontal hairline.
See your GP or seek medical advice if: