Does Prolia Cause Any Eye
No, in clinical trials of Prolia there werent any eye-related side effects reported. However, certain other medications used to treat osteoporosis may cause eye-related side effects. This includes medications such as risedronate and alendronate .
The eye-related side effects that certain drugs other than Prolia may cause include:
- swelling in your eye
- long-term vision problems, in some cases
However, there havent been reports of Prolia causing these eye-related side effects.
If you have any issues with your eyes during Prolia treatment, talk with your doctor. They can check to see whats causing your eye issues, and theyll recommend whether you need medical treatment.
How Is Romosozumab Given
The medication is injected once a month using two separate prefilled syringes for a full dose. Romosozumab should only be taken for one year, because its bone-making activity wanes after 12 months. Women using this therapy should also make sure they get enough calcium and vitamin D during treatment.
How Does Prolia Work
is the brand name for the generic drug denosumab. It inhibits a protein called RANKL. The cells responsible for breaking down bone need RANKL in order to work and survive. By keeping RANKL from binding to its receptor, Prolia limits the ability of these cells to break down bone.
As a result, Prolia helps strengthen bone and increase bone mass. Like Reclast, Prolia also helps reduce the occurrence of various fractures, including vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis.
Prolia is also approved to treat several different groups of people:
Men and postmenopausal women with osteoporosis who are at high risk for bone fractures, including those with osteoporosis caused by steroids
Men who are at high risk for bone fractures and are receiving androgen deprivation therapy like or for nonmetastatic prostate cancer treatment
Women who are at high risk for bone fractures and are receiving adjuvant aromatase inhibitor therapy like for breast cancer treatment
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Should I Be Concerned About Osteonecrosis When Using Tymlos
No. You shouldnt be concerned about osteonecrosis while youre taking Tymlos. Osteonecrosis isnt a side effect of the drug.
With osteonecrosis, bones dont have enough blood flow and a result, some bone can die. The condition can cause painful bones.
However, other medications used to treat osteoporosis may cause osteonecrosis. Examples of these medications include:
Keep in mind that using Tymlos shouldnt lead to osteonecrosis.
What Are The Possible Side Effects Of Tymlos
TYMLOS can cause serious side effects including:
- Some people may feel dizzy, have a faster heartbeat, or feel lightheaded soon after the TYMLOS injection is given. These symptoms generally go away within a few hours. Take your injections of TYMLOS in a place where you can sit or lie down right away if you get these symptoms. If your symptoms get worse or do not go away, stop taking TYMLOS and call your healthcare provider.
- Increased blood calcium . TYMLOS can cause some people to have a higher blood calcium level than normal. Your healthcare provider may check your blood calcium before you start and during your treatment with TYMLOS. Tell your healthcare provider if you have nausea, vomiting, constipation, low energy, or muscle weakness. These may be signs there is too much calcium in your blood.
- Increased urine calcium . TYMLOS can cause some people to have higher levels of calcium in their urine than normal. Increased calcium may also cause you to develop kidney stones in your kidneys, bladder or urinary tract. Tell your healthcare provider right away if you get any symptoms of kidney stones which may include pain in your lower back or lower stomach area, pain when you urinate, or blood in your urine.
The most common side effects of TYMLOS include:
- upper stomach pain
- spinning feeling
These are not all the possible side effects of TYMLOS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Is Tymlos Safer Than Forteo
Is forteo a safe drug?
These include men and women with either a history of broken bones, who have several risk factors for fracture, or who can not use other osteoporosis treatments. It is not known if FORTEO issafe and effective in children. FORTEO should not be used in children and young adults whose bones are still growing.
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Can You Take Reclast And Prolia Together
Reclast and Prolia should not be taken together. Theres no information available about whether taking both together would add to their effectiveness. But more importantly, the risk of major side effects like hypocalcemia, osteonecrosis of the jaw , atypical fractures, and severe bone, joint, and muscle pain would likely be increased by taking both of these medications together.
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What Are Common Side Effects Of Reclast And Prolia
While there are some differences between the two medications as far as side effects and warnings go, there are also several similarities.
The most common side effects of Reclast include:
Prolia can also cause serious skin infections like cellulitis and other serious infections like endocarditis, a heart infection.
In addition, youll want to be aware of these three risks with either medication:
Osteonecrosis of the jaw : You should have a dental exam before starting either medication so that your healthcare team can assess your risk for developing ONJ, which can cause your jawbone to weaken severely. A history of dental issues can make you more likely to experience this side effect, and major dental procedures like surgeries can make ONJ worse if you already have it. But rest assured that ONJ is rare when these medications are used to treat osteoporosis.
Atypical fractures: You may not notice these fractures as much because they dont cause much trauma. But if you notice new thigh, hip, or groin pain during treatment with either of these medications, it may be a sign of an atypical fracture. Let your healthcare provider know right away.
Pain: Severe bone, joint, and muscle pain are also common side effects of both medications.
What About Natural Supplements For Osteoporosis
Right now, there are no natural supplements that experts recommend in lieu of FDA-approved osteoporosis drugs. If youve been searching the internet for that, youve probably come across info on strontium, a trace element, for osteoporosis.
There is some scientific basis on this one. A study found that postmenopausal women who took two grams of strontium ranelate every day for three years suffered 37 percent fewer spinal fractures compared to women taking a daily placebo pill.
Theres also a strontium ranelate-based drug approved in Europe, but not here in the US. So, should you take an over-the-counter version of the mineral, such as strontium citrate or strontium chloride, to strengthen your bones? Not so fast. These are not the same as strontium ranelate, and theres no evidence they work.
What about OTC estrogen pills? Phytoestrogens, plant-based versions of the hormone such as soy and flaxseed, have some limited data behind them to show that they may help slow bone loss. But physicians say not enough to replace your prescribed medication. Phytoestrogens in your diet may be better at preventing low bone density than treating osteoporosis.
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Side Effects And Risks
Tymlos and Forteo both contain forms of parathyroid hormone. So these medications can cause very similar side effects, but some different ones as well. Below are examples of these side effects.
Mild side effects
These lists contain up to 10 of the most common mild side effects that can occur with Tymlos and Forteo, as well as mild side effects that both drugs may share.
- Can occur with Tymlos:
- pain in the upper belly
boxed warning regarding the risk of bone cancer. A boxed warning is the strongest warning required by the Food and Drug Administration . Boxed warnings alert doctors and patients about drug effects that may be dangerous. For more information on this warning for Tymlos, see FDA warning: Risk of bone cancer above.
Which Works Better For Osteoporosis
Both Reclast and Prolia are powerful osteoporosis medications. In a small study with 107 participants, people who received Prolia and those who got Reclast saw similar improvements in their bone mineral density , a measure of bone health.
A larger study compared the drugs to each other, focusing primarily on the risk of serious infections, heart disease, or bone fractures. The risk of each was similar for both medications.
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What Does Research Tell Us
Two large trials in The New England Journal of Medicine have looked at this new medication. One trial enrolled over 7,000 postmenopausal women with osteoporosis based on low bone density measurements. Half received romosozumab and half placebo for one year. Women using romosozumab versus placebo had far fewer new vertebral fractures: 16 in the treatment group, 59 in the placebo group.
In the second year of the study, all participants including those who had been taking a placebo were given the anti-resorptive agent denosumab. The group that received romosozumab followed by denosumab had 21 vertebral fractures, compared to 84 in the group that received placebo followed by denosumab.
Another trial enrolled more than 4,000 postmenopausal women with osteoporosis and a history of related fractures. Half were treated with a monthly injection of romosozumab for one year, followed by alendronate once a week for the second year. The other half received alendronate once a week for both years.
At the end of the study:
- those assigned to receive romosozumab in the first year had fewer new spine fractures than those receiving alendronate for both years
- hip fractures also occurred less often among those receiving romosozumab
- bone density was higher in the group that received romosozumab.
Osteonecrosis Of The Jaw
Each of these medications can also cause a serious but rare condition called osteonecrosis of the jaw that causes your jawbone to weaken severely. Your healthcare provider may recommend a dental exam before starting one of these treatments to assess your risk for developing ONJ. Make sure to let your dentist know if you are taking one of these medications.
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Is Forteo Safer Than Prolia
Prolia is stronger than Reclast and may actually help you make more bone. Both of these medications are better alternatives than the pills due to the reflux. But if you already had fractures related to bone density, medications such as teriparatide or denosumab may be more appropriate.
Can Forteo cause cancer?
During drug testing, the medicine in FORTEO caused some rats to develop a bone cancer called osteosarcoma. In people, osteosarcoma is a serious but rare cancer. Osteosarcoma has rarely been reported in people who took FORTEO. It is not known if people who take FORTEO have a higher chance of getting osteosarcoma.
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How Much Do Reclast And Prolia Cost
Both of these drugs are expensive, and there are currently no generic alternatives. But most Medicare and insurance plans will cover Reclast and Prolia.
The average cash price of Prolia is $1,804.25. Using a GoodRx discount can bring down the cost to $1,265.33. The average cash price of Reclast is around $1,100.
How To Use Tymlos Pen Injector
Read the Medication Guide and Instructions For Use provided by your pharmacist before you start using abaloparatide and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.
Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin.
Inject this medication under the skin of the abdomen area as directed by your doctor, usually once daily. When you give the first several doses, make sure you are in a place where you can sit or lie down if you have dizziness.
Learn how to store and discard medical supplies safely.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.
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Side Effects Requiring Immediate Medical Attention
Along with its needed effects, abaloparatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking abaloparatide:
- pain in the bone, joint, back, arms, or legs
- pain in the side, back, or stomach
- trouble breathing
Research Shows Bisphosphonates Can Cause Hair Loss
A group of Dutch researchers reviewed 53 reports of bisphosphonate-induced alopecia. Participants took alendronate or risendronate the vast majority of alopecia reports concerned alendronate.
While the exact mechanism of bisphosphonate induced alopecia is unknown,1 the researchers concluded that its most likely due to the fact that bisphosphonates block a particular enzyme, thereby interfering with an enzymatic pathway.1
Sounds familiar? If it does, its because Ive devoted many pages of the Osteoporosis Reversal Program to give an explanation of
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How Are Prolia And Xgeva Different From Each Other
Prolia and Xgeva both contain the same active drug called denosumab. But these medications have different approved uses.
Prolia is approved to treat osteoporosis and to increase bone mass in certain people. However, Xgeva is approved for the following uses:
- preventing certain bone problems in people with multiple myeloma*
- preventing certain bone problems in people with cancer that has spread to their bones
- treating high blood calcium levels that are caused by cancer
- treating a certain type of bone cancer that cant be treated with surgery
Prolia and Xgeva are each given as injections under your skin . However, Prolia is given once every 6 months, while Xgeva is given once every 4 weeks. The doses of these drugs also differ. If youre taking Prolia, youll receive a 60-mg dose with each injection. But if youre taking Xgeva, youll receive a 120-mg dose with each injection.
You shouldnt take Prolia and Xgeva at the same time. If you have questions about which medication is right for you, talk with your doctor.
* Multiple myeloma is type of cancer that affects your white blood cells.