Risk Of Bone Fractures After Skipping Or Stopping Treatment
Skipping a dose of Prolia or stopping use of the drug increases the risk of bone fractures. This includes an increased risk of multiple bone fractures in the spine.
When stopping Prolia, bone turnover increases to above-normal values 9 months after the last dose. Bone turnover refers to how quickly your bones replace old bone tissue with new bone tissue. Bone turnover usually takes 24 months after the last dose of Prolia to return to normal.
What might help
If you use Prolia, youll likely get an injection once every 6 months. To avoid an increased risk of bone fractures, its important that you dont miss a dose. If you do miss an injection, call your doctor or pharmacy to reschedule as soon as possible.
If you and your doctor agree that its best for you to stop using Prolia, ask your doctor about other medications you could take. They may recommend another treatment for your condition to help your bones stay strong and healthy.
Is Prolia Safe To Take Are There Any Dangers Of Using This Drug
For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo.
Side effects are possible with Prolia use, but in most cases they go away after a while. Some rare side effects of Prolia can be serious and need medical attention. These side effects include:
- jaw necrosis
Your for these serious side effects may be higher if youre older and have certain dental procedures. Your risk may also be higher if you:
- have other health conditions, such as kidney disease
- take other medications, such as corticosteroids or chemotherapy drugs
Stopping Prolia treatment can also increase your risk for bone fractures. So, if you want to stop taking Prolia, talk with your doctor. Theyll discuss with you other treatments to help prevent bone loss.
If youre concerned about side effects with Prolia, talk with your doctor. They can explain the risks and benefits of this drug. And theyll recommend if its the best option for your condition.
Prolia Injection Side Effects
Prolia can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Prolia. These lists dont include all possible side effects.
For more information on the possible side effects of Prolia, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.
Note: The Food and Drug Administration tracks side effects of drugs they have approved. If you would like to report to the FDA a side effect youve had with Prolia, you can do so through MedWatch.
Your side effects may vary from those listed below, depending on the condition youre using Prolia to treat.
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Prolia With Other Prescription Drugs To Improve Bone Strength
In some cases, your doctor may recommend that you take another prescription drug with Prolia to help improve your bone strength. These other prescription drugs could include:
Your doctor will let you know whether youll need to take any other prescription medications with Prolia.
Jaw And Dental Side Effects
Dental and jaw-related side effects have rarely been reported with Prolia treatment. These side effects may include:
- loose teeth
- mouth infection
- pain or numbness in your jaw
Its not known what percentage of people in clinical trials developed dental or jaw-related side effects.
A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. According to the American Dental Association, your risk of this problem may increase if you receive denosumab for longer than 2 years.
What you can do
Before you start Prolia treatment, your doctor will examine the inside of your mouth. They may also have you see your dentist. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated.
Its important to practice good oral hygiene during Prolia treatment. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings.
If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Treating any mouth or dental problems early is the best way to help prevent serious dental complications.
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What To Ask Your Doctor
Prolia may help treat your osteoporosis. But the drug may also cause side effects. Most of these side effects arent common. When they occur, side effects are typically mild and go away on their own after a few days. But in rare cases, Prolia can cause serious side effects.
If you have questions about Prolias side effects, talk with your doctor or pharmacist. Asking questions can help you feel more prepared and confident in your treatment. Here are a few questions to get you started:
- Are there ways to reduce my risk for side effects from Prolia?
- Do any of the medications I take increase my risk for Prolias side effects? If so, which side effects?
- I receive dialysis. How might this affect potential side effects of Prolia?
If I Experience Side Effects From Prolia Can They Be Reversed
Its possible, depending on the side effect. Some Prolia side effects can be treated. For example:
- Mild pain, such as in the muscles or joints, or a headache. Your doctor may recommend using an over-the-counter pain reliever, such as Tylenol or Advil , to treat this side effect.
- Bladder infection. For this side effect, your doctor will likely prescribe an antibiotic.
- Bone production typically returns to normal about 24 months after your last dose of Prolia.
Your doctor will choose the best treatment for you based on your health and the side effects Prolia is causing. If you have questions about treating side effects from Prolia, talk with your doctor.
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Stopping Hair Loss Naturally
The good news is that if you have taken osteoporosis drugs before or you are simply experiencing hair loss as part of aging, there are ways for you to naturally stop hair loss AND build bone.
One of the best ways to do this is through diet. The right foods can nourish your hair follicles and promote growth, so next well discuss the foods that have been scientifically shown to promote hair growth.
Drug Forms And Strengths
Prolia comes as a solution inside prefilled syringes that each hold 60 mg of the drug. Prolia is given as an injection under your skin . The drug can be injected into your upper thigh, upper arm, or abdomen . Youll get Prolia injections from a healthcare professional at your doctors office.
Rarely, your doctor may give you the option to self-inject Prolia at home. For more information, see How Prolia injection is administered below.
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Drug Forms And Administration
Prolia is given by healthcare professionals as an injection under your skin . Youll get Prolia injections in your doctors office once every 6 months.
Reclast is given as an intravenous infusion. With an IV infusion, the drug is injected into your vein over a period of time. Youll get Reclast infusions at your doctors office once every 1 to 2 years.
Prolia For Men Using Androgen Deprivation Therapy For Nonmetastatic Prostate Cancer
Prolia is approved to increase bone mass in males with nonmetastatic prostate cancer who are using androgen deprivation therapy.
Androgen deprivation therapy is a treatment option for prostate cancer. It works by blocking androgens , such as testosterone. Androgens encourage prostate cancer to grow and spread in your body. By blocking androgens, these therapies can help treat prostate cancer.
However, certain hormones help to keep you bones strong and healthy. Because ADT affects your hormones, it can also affect your bone density. One study showed that after only 6 to 12 months of ADT, males lost bone mineral density * at a rate that was 17.3% faster than males who werent taking these treatments.
* BMD is a measurement that shows how strong your bones are.
Effectiveness in men using androgen deprivation therapy
In clinical trials, Prolia was an effective treatment to increase bone mass in males taking certain medications that decrease androgen levels. Some males were given injections of Prolia, while other males were given injections of a placebo . In this study, BMD was measured to evaluate how strong the males bones were.
Compared with males taking the placebo, after 36 months of treatment, males taking Prolia had BMD that was increased by:
- 7.9% in their spine
- 5.7% higher in their hip
- 4.9% higher in their femoral neck
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What Medications Can Cause Hair Loss 46 Known Drugs
Losing your hair or dealing with baldness can be incredibly frustrating.
As you age, itâs also not altogether unexpected: a majority of men will deal with hair loss sometime in their life due to natural causes, but it can be delayed â and hair restored â with proper hair loss treatment.
But medications for other conditions can also cause hair loss, and certain drugs can contribute not only to hair loss but excessive hair growth and changes in color and texture as well.
Thereâs good news though, as these changes in your hair are typically reversible once you stop taking the drug thats causing them. Hereâs what you should know about medications and hair loss.
Can You Take Reclast And Prolia Together
Reclast and Prolia should not be taken together. Theres no information available about whether taking both together would add to their effectiveness. But more importantly, the risk of major side effects like hypocalcemia, osteonecrosis of the jaw , atypical fractures, and severe bone, joint, and muscle pain would likely be increased by taking both of these medications together.
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How Can Medication Cause Hair Loss
Some medications can cause hair loss because they interfere with the normal cycle of scalp hair growth. Healthy hair growth will occur at a rate of roughly 0.35 millimeters per day, which is roughly half of an inch per month. In addition, most healthy men and women will have between 80,000 and 120,000 terminal hairs on their scalp.
Hair follicles, of which you have tens of thousands on your head, each cycle through three primary phases: anagen, catagen, and telogen.
Medications can lead to two different types of hair loss: telogen effluvium and anagen effluvium.
Pregnancy And Breastfeeding While Using Prolia
Pregnancy. You shouldnt use Prolia if youre pregnant or planning to become pregnant. The drug may harm a developing fetus. Before starting Prolia treatment, your doctor may give you a pregnancy test to make sure youre not pregnant.
If you can become pregnant, you should use an effective form of birth control during Prolia treatment. And you should continue to use birth control for at least 5 months after your last dose of the drug.
Talk with your doctor about safe treatments for your condition if youre pregnant or planning to become pregnant.
Breastfeeding. It isnt known whether Prolia passes into human breast milk. It also isnt known if Prolia in breast milk could cause side effects in a breastfed child. The manufacturer recommends either using Prolia or breastfeeding, but not both.
Talk with your doctor about the best treatment and feeding options for your situation.
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How Does This Medication Work What Will It Do For Me
Denosumab belongs to a family of medications known as monoclonal antibodies. Specifically, it inhibits a protein that your body uses to signal for removing old bone tissue. Denosumab works by reducing the amount of bone your body breaks down, making your bones less likely to break.
Denosumab is used to treat osteoporosisfor postmenopausal women who have a high risk of fracture or who have not tolerated or responded to other osteoporosis medications. It is also used to increase bone mass in men who have osteoporosis and are at high risk of having a fracture, have a history of osteoporotic fracture, or have not tolerated or responded to other osteoporosis medications.
This medication is also is also used to increase bone mass for women who are being treated with an aromatase inhibitor for breast cancer that has not spread to other parts of the body. It is also used to increase bone mass and reduce fractures for men who have prostate cancer that has not spread to other parts of the body and who are receiving medication to reduce testosterone levels.
Denosumab may also be used to increase bone mass for men and women who are taking or have just started to take glucocorticoids for a long period of time.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
Pregnancy And Breastfeeding While Taking Prolia
Heres some information on pregnancy, breastfeeding, and Prolia use.
Pregnancy. It is not safe to receive Prolia during pregnancy. The drug may increase the risk of pregnancy loss. Prolia can also cause bones to not form correctly and reduced growth in a fetus.
If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Theyll need to confirm that you arent pregnant.
Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. If you have a male* sexual partner, they should use birth control during this time as well.
Breastfeeding. If youre breastfeeding, you should not receive Prolia. This is because its not known if Prolia is safe to receive while breastfeeding.
Talk with your doctor
If youre pregnant or breastfeeding, or considering either, talk with your doctor. They can recommend a treatment option other than Prolia.
* Sex and gender exist on spectrums. Use of the term male in this article refers to sex assigned at birth.
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What Are Common Side Effects Of Reclast And Prolia
While there are some differences between the two medications as far as side effects and warnings go, there are also several similarities.
The most common side effects of Reclast include:
Prolia can also cause serious skin infections like cellulitis and other serious infections like endocarditis, a heart infection.
In addition, youll want to be aware of these three risks with either medication:
Osteonecrosis of the jaw : You should have a dental exam before starting either medication so that your healthcare team can assess your risk for developing ONJ, which can cause your jawbone to weaken severely. A history of dental issues can make you more likely to experience this side effect, and major dental procedures like surgeries can make ONJ worse if you already have it. But rest assured that ONJ is rare when these medications are used to treat osteoporosis.
Atypical fractures: You may not notice these fractures as much because they dont cause much trauma. But if you notice new thigh, hip, or groin pain during treatment with either of these medications, it may be a sign of an atypical fracture. Let your healthcare provider know right away.
Pain: Severe bone, joint, and muscle pain are also common side effects of both medications.
Pregnancy And Breastfeeding During Prolia Treatment
Below are details about taking Prolia during pregnancy or while breastfeeding.
Pregnancy and Prolia
You should not take Prolia if you are pregnant. Prolia may cause harm to a developing fetus. However, there arent any clinical studies in humans to determine what risks Prolia may cause to a developing fetus. In animal studies, the drug increases the risk of pregnancy loss and congenital anomalies . Animal studies do not always indicate what may happen in humans.
However, due to this risk, your doctor will recommend that you do not take Prolia if you are pregnant or planning to become pregnant. In fact, your doctor will recommend that you take a pregnancy test before starting treatment with Prolia to be sure that you arent pregnant.
In addition, its recommended that people who can become pregnant use an effective form of birth control during treatment with Prolia. You should continue using birth control for 5 months after your last dose of Prolia.
Breastfeeding and Prolia
Its not known what effects Prolia may have on a breastfeeding child or on the ability to produce breast milk. In animal studies, Prolia was present in breast milk. However, animal studies do not always indicate what may happen in humans.
Due to this risk, your doctor will likely recommend that you do not use Prolia while youre breastfeeding. If you would like to breastfeed after taking Prolia, talk with your doctor about when it may be safe to do so.
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