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Does Prolia Cause Hair Loss

Is Prolia Used For Other Conditions

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In addition to treating osteoporosis, which is described just above, Prolia also has other uses.

Its used to lower the risk of bone fractures in people with certain other conditions. Specifically, its used to increase bone mass in:

Osteopenia , and low bone mineral density can occur with older age. They can also happen if you have certain conditions or if you take certain medications.

With low BMD your bone tissues have less mineral, which means they become weaker. With bone loss, your body loses old bone tissue faster than it makes new bone tissue. So, your bones become weak and brittle. This increases your risk for bone fractures.

If youve already gone through menopause, your risk for bone loss is increased.

Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. Theyll do this with certain tests, such as a bone scan or ultrasound.

Prolia improves bone mass and increases bone mineral density. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones.

In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Examples of conditions Prolia is used off-label to treat include:

Known Drugs That Can Cause Hair Loss

Drug induced alopecia, hair loss that develops due to a side effect of medication, will often occur within three months after starting the particular medication, but the exact timeline will depend on a few factors. The type of drug, type of hair loss, dosage, and your sensitivity to the drug are all important factors in how severe the side effects will be.

What Are The Dangers Of Using Prolia

Most people who use Prolia dont have serious side effects. But as with many other drugs, serious side effects can occur with Prolia. For more information, see the What are the serious side effects of Prolia? section above.

You could be at higher risk for certain side effects due to other medical conditions you may have. To learn more, see the Warnings for Prolia section below.

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Could Hair Loss Be A Side Effect Of Prolia

Hair loss wasnt reported as a side effect during clinical studies of Prolia. But hair loss has been reported by people who have taken Prolia since then.

With these reports, it wasnt known whether Prolia or something else caused the hair loss.

If youve noticed hair loss since starting Prolia treatment, talk with your doctor. They may help you identify other possible causes or suggest ways to help manage hair loss.

Is Prolia Used For Osteopenia Or Arthritis

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Prolia isnt approved to treat osteopenia or arthritis.

With osteopenia, your bone mineral density is lower than normal. This means your bones may be weaker than normal. As you age, your BMD is reduced, and this may increase your risk for osteoporosis.

With arthritis, you have pain and inflammation of your joints. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis . RA is an autoimmune condition in which your immune system attacks your joints.

Prolia may be used off-label for RA, if you have a high risk for bone fractures.

The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis.

If you have questions about treatment options for osteopenia or arthritis, talk with your doctor.

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Is Prolia Safe To Use

Yes, Prolia is safe and effective to treat osteoporosis and to prevent bone loss in certain people.

In fact, before Prolia was approved by the Food and Drug Administration , the drugs safety was tested. For all of Prolias approved uses, the drug was shown to be a safe medication.

During clinical studies, serious side effects were seen in some people using Prolia. But serious side effects occurred in some people using a placebo . For example, of people taking Prolia, serious side effects were seen in:

  • 25% of women with osteoporosis whod already gone through menopause. In comparison, for women taking a placebo, 24.2% had serious side effects.
  • 8.3% of men with osteoporosis. In comparison, for men taking a placebo, 7.5% had serious side effects.
  • 16% of people with osteoporosis that was caused by certain corticosteroids. In comparison, for people taking a different drug called risedronate, 17% had serious side effects.
  • 34.6% of men using certain prostate cancer drugs who took Prolia to prevent bone loss. In comparison, for men taking a placebo, 30.6% had serious side effects.
  • 14.7% of women using certain breast cancer drugs who took Prolia to prevent bone loss. In comparison, in women taking a placebo, 9.2% had serious side effects.

For information about the serious side effects that Prolia may cause, see the section Prolia side effects above.

If you have questions about Prolias safety, talk with your doctor.

Is Tingling A Side Effect Of Prolia

Tingling wasnt specifically reported as a side effect of Prolia in clinical studies. But tingling may be a symptom of side effects such as sciatica and hypocalcemia.

Sciatica is described as a shooting pain that travels from the lower back down a leg. Weakness and tingling can also occur. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause.

Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. If you have low calcium levels, you should not take Prolia.

If youre concerned about tingling while using Prolia, talk with your doctor.

* Sex and gender exist on spectrums. Use of the term female in this article refers to sex assigned at birth.

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The Link Between Osteoporosis Drugs And Hair Loss

When I was first diagnosed with osteoporosis, I was prescribed the popular bisphosphonate Fosamax. I was shocked to learn that hair loss was one of the many terrible side effects of this drug, and to this day Im so glad I never took it. Bisphosphonates like Fosamax, Actonel, Boniva, and Reclast have been tied to alopecia.

In a study conducted by a group of Dutch researchers, participants took alendronate or risedronate the vast majority of alopecia reports came from those taking alendronate.

The researchers noted that the exact mechanism of bisphosphonate induced alopecia is unknown, but that its most likely because bisphosphonates block a particular enzyme, thereby interfering with an enzymatic pathway.

Bisphosphonates impact bone metabolism by blocking the enzyme farnesyl diphosphate synthase which is involved in the mevalonate pathway . The Osteoporosis Reversal Program, 2007

The mevalonate pathway is essential to the production of cholesterol, which can help explain why bisphosphonates impact hair loss.

Our hair contains cholesterol and the cholesterol in our hair follicles is partly absorbed and partly synthesized in hair follicles through the HmG-CoA-reductase pathway. We know that statins, a popular type of drugs prescribed to lower cholesterol, also disrupt this pathway.

Risk Of Bone Fractures After Skipping Or Stopping Treatment

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Skipping a dose of Prolia or stopping use of the drug increases the risk of bone fractures. This includes an increased risk of multiple bone fractures in the spine.

When stopping Prolia, bone turnover increases to above-normal values 9 months after the last dose. Bone turnover refers to how quickly your bones replace old bone tissue with new bone tissue. Bone turnover usually takes 24 months after the last dose of Prolia to return to normal.

What might help

If you use Prolia, youll likely get an injection once every 6 months. To avoid an increased risk of bone fractures, its important that you dont miss a dose. If you do miss an injection, call your doctor or pharmacy to reschedule as soon as possible.

If you and your doctor agree that its best for you to stop using Prolia, ask your doctor about other medications you could take. They may recommend another treatment for your condition to help your bones stay strong and healthy.

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More Common Side Effects Of Prolia

Prolia can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Common side effects of Prolia can vary depending on which condition the drug is being used to treat.

More common side effects in females* who received Prolia for osteoporosis after menopause included:

  • pain in bones and muscles, including back, arm, and leg pain

More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included:

  • joint pain
  • pain in bones and muscles, including back, arm, and leg pain

For a complete list of all the side effects reported with Prolia, see the drugs full prescribing information.

* Sex and gender exist on spectrums. Use of the terms female and male in this article refers to sex assigned at birth. To learn more information about this side effect, see Side effect specifics below.

Is Tymlos Safer Than Forteo


Is forteo a safe drug?

These include men and women with either a history of broken bones, who have several risk factors for fracture, or who can not use other osteoporosis treatments. It is not known if FORTEO issafe and effective in children. FORTEO should not be used in children and young adults whose bones are still growing.

what is the safest medication for osteoporosis?treat osteoporosistreat osteoporosis


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Mild Side Effects Of Prolia

Mild side effects can occur with Prolia use. This list doesnt include all possible mild side effects of the drug. And some of these side effects are more common with certain uses of Prolia. For more information, you can refer to the drugs medication guide.

Mild side effects that have been reported with Prolia include:

  • pain in bones* and muscles, including back, arm, and leg pain
  • joint pain
  • constipation

These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see Side effect specifics below.

Prolia: What To Discuss With Your Doctor

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Talk with your doctor or pharmacist to find out more information about Prolia. If you have questions about the drugs side effects, your pharmacist or healthcare professional can help answer them for you.

In addition to discussing Prolia with your doctor, you may find the following articles helpful in learning more.

  • Overview of Prolia. To read an overview of Prolia, see this article.
  • Drug comparison. To learn how Prolia compares with Reclast, read this article.
  • Details about osteoporosis. To learn more about osteoporosis, which Prolia is used to treat, see this article.

Disclaimer: Healthgrades has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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A Hair Loss Side Effect Story:

Q. I am very upset about a side effect of beta blockers. These drugs are widely prescribed for blood pressure and other problems and a huge number of people are taking them. But they make our hair fall out! This is devastating for a woman.

I have appealed to my cardiologist to help me with this problem and she has offered to switch me from carvedilol to metoprolol . If this doesnt work, whatll I do?

A. Beta blockers like atenolol, carvedilol, metoprolol and propranolol can lead to hair loss. No one knows how common this complication is because it has not been considered a serious side effect . Patients have a very different perspective!).

One reader reported her experience with a different beta blocker:

I started drastically losing my hair soon after starting on atenolol. My doctor was reluctant to take me off of it since it was working so well in lowering my blood pressure. But there are many meds to take for hypertension, so dont let your doctor keep you on any one medication if you are experiencing side effects that bother you.

Hair loss from atenolol IS reversible. My hair grew back completely in less than six months. Its taken me a few years of trial and error to find the drugs that work best for my blood pressure without side effects.

How Can A Drug Help Hair Loss

Researchers in the United Kingdom think they have a solution to hair loss. They believe that a drug commonly used to treat osteoporosis may be able to help people to restore hair growth after hair loss begins. This information comes from a study that took place at the University of Manchesters Center for Dermatology Research. The researchers there found a compound that could potentially stop the impact of a protein that commonly suppresses hair growth within the scalps follicles. How could this happen?

Initially, the studys researchers began work using a drug called Cyclosporine A. This is a common drug used to treat advanced osteoporosis in many areas. This drug works to treat other types of autoimmune diseases as well. It also helps to reduce organ transplant rejection. In short, it is not a new product or drug. But, researchers also knew it would lead to side effects. And, it did. The side effects from this particular drug were simply too severe to warrant it as an effective treatment for hair loss. So, they took the same principle and moved on.

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